Old Work

HCL Projects in detail

Erectile Dysfunction

User research & conceptualization

·         User research and identifying unmet needs in the market

·         Conceptualization and presentation of a set of device solutions for Erectile dysfunction

·         Modeling and analyzing the physiology and mechanism of erection to assist device development

·         Designing specialized solutions to avoid catheter-associated urinary tract infection

Proof of Concept and device design

1) Electromagnetic device for erectile dysfunction

Design of the device which applies electromagnetic wave for opening of the potassium channels resulting in minimal intracellular calcium which relaxes the smooth muscles of cavernosal artery resulting in erection.

·         Literature review for determining different biomechanical and molecular parameters necessary for the design such as pressure of cavernosal artery during erection, blood flow velocity change during erection etc.

·         Designing the device taking the manufacturing feasibility, functionality and form into consideration.

·         Mathematically modeling the device-tissue interactions using a set of biophysical equations

§ Mathematical model of EM wave- tissue interactions(noise-induced resonance) in cellular to macro level fluidics

§ mathematical model of calcium dynamics

§ Transient heat transfer

·         Solving the problem numerically and semi analytically for dynamic and steady state cases to determine design parameters such as intracellular change in calcium concentration, magnetic field required, current, power, temperature change of the skin.

2) LED device for erectile dysfunction

Design of the device which applies LED (light emitting diode) illumination for nitric oxide release from epithelial cells which diffuses into the arteries relaxing those smooth muscles of cavernosal artery resulting in penile erection.

·         Literature review for determining different biomechanical and molecular parameters necessary for the design such as pressure of cavernosal artery during erection, blood flow velocity change during erection etc.

·         Designing the device taking the manufacturing feasibility, functionality and form into consideration.

·         Mathematically modeling the device-tissue interactions using a set of biophysical equations

§ Mathematical model of light- nitric oxide tissue interactions in cellular to macro level fluidics

§ mathematical model of nitric oxide diffusion

§ Transient heat transfer

·         Solving the numerical model using finite differences to determine the parameters necessary for the design such as nitric oxide required for erection, wavelength and radiance of light needed, number of LEDs, Power, Time for the action of the device, temperature rise in the skin etc.

·         The results of the numerical model were compared with literature to validate the results.

Urinary Incontinence

User research & conceptualization

·         User research and identifying unmet needs in the urology market

·         Insight matrix and hierarchical clustering were used in finding the insights and design directions.

·         Conceptualization and presentation of a set of device solutions for the condition known as urinary incontinence.

·         The concepts ranged from simple mechanical design solutions to prevent urethral trauma to electromechanical devices linking the bimolecular and biomechanical aspects of human physiology.

·         Doing the feasibility study and development of a technical development matrix for external devices for urinary incontinence taking engineering design, manufacturing feasibility and biocompatibility into consideration.

·         Numerically modeling and analyzing the urethra and the urethrovesical junction to assist in device design

·         Designing specialized solutions to avoid catheter-associated urinary tract infection.

·         Developing a new concept selection algorithm (available here)